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Comprehensive profiling of the early lung immune responses in the mouse model of tuberculosis

ABSTRACT: The lung host immune responses following M.tuberculosis infection in the mouse model of tuberculosis were assayed by studying the gene expression profiles at day 0, day 12, 15 and 21 post infection

ORGANISM(S): Mus musculus

PROVIDER: GSE23014 | GEO | 2010/07/21

SECONDARY ACCESSION(S): PRJNA131515

REPOSITORIES: GEO

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Comprehensive profiling of the early lung immune responses in the mouse model of tuberculosis

Project description:The lung host immune responses following M.tuberculosis infection in the mouse model of tuberculosis were assayed by studying the gene expression profiles at day 0, day 12, 15 and 21 post infection Mice were infected with M.tuberculosis via the aerosol route and the host gene induction during early immune response studied

2010-07-21 | E-GEOD-23014 | biostudies-arrayexpress

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Project description:Transcriptional profiling of M.tuberculosis was performed using 430 whole-genome microarrays to measure the effects of 75 different drugs, drug combinations or different growth conditions at various times relative to a sample of logarithmically growing MTb. Analysis of this data set revealed 150 underlying clusters of coordinately regulated genes as described in Boshoff et al., 2004. Keywords = Gene clusters Keywords = Mechanism of action Keywords = tuberculosis Keywords = antimycobacterial drugs Keywords = natural product Keywords = respiration Keywords: other

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