Estrogens and selective estrogen receptor modulators regulate gene and protein expression in the mesenteric arteries

ABSTRACT: Estrogen is a reproductive steroid hormone that has both beneficial and detrimental effects on the cardiovascular system. Selective estrogen receptor modulators (SERMs) exhibit partial estrogen agonist/antagonist activity in estrogen target tissues. Since we still have an incomplete picture of the gene targets of estrogen in the vasculature, and our understanding of SERM gene targets in the vasculature is even less well-developed, it is important to broaden the available information on this subject. The present study tested the hypothesis that estrogens (ethinyl estradiol, estradiol benzoate, and equilin) and SERMs (tamoxifen and raloxifene) cause differential gene and protein expression in the vasculature. DNA microarray and real-time RT-PCR were used to investigate gene expression in

ORGANISM(S): Rattus norvegicus

SUBMITTER: Kathleen Eyster 

PROVIDER: E-GEOD-23037 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress