Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

Comparative gene expression analysis of mesenchymal stem cells (MSC) derived from non-small cell lung cancer (NSCLC) and corresponding normal lung tissue (NLT)

ABSTRACT: The stromal microenvironment plays a vital role in cancer initiation and progression. We performed a comparative expression profiling of pulmonary MSC derived from NSCLC and corresponding normal lung tissue of 5 newly diagnosed patients. The analysis indicated variable expression of genes involved in DNA repair, apoptosis, proliferation or angiogenesis between NSCLC-MSC and NLT-MSC. MSC were derived from NSCLC and corresponding normal lung tissue of 5 patients. Paired SAM test was performed to screen for differentially expressed genes between NSCLC-MSC and NLT-MSC.

ORGANISM(S): Homo sapiens

SUBMITTER: Ruprecht Kuner

PROVIDER: E-GEOD-23066 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Mesenchymal stem cells in non-small cell lung cancer--different from others? Insights from comparative molecular and functional analyses.

Gottschling Sandra S Granzow Martin M Kuner Ruprecht R Jauch Anna A Herpel Esther E Xu Elizabeth Chang EC Muley Thomas T Schnabel Philipp A PA Herth Felix J F FJ Meister Michael M

Lung cancer (Amsterdam, Netherlands) 20130105 1

<h4>Background</h4>Cancer-associated fibroblasts (CAF) play a vital role in lung cancer initiation and progression. Although mesenchymal stem cells (MSC) are considered progenitor cells of fibroblasts and show cancer modulating abilities themselves, analyses on their presence and properties in lung cancer are lacking so far.<h4>Methods</h4>We performed a comparative molecular and functional analysis of MSC derived from non-small cell lung cancer (NSCLC) and corresponding normal lung tissue (NLT) ...[more]

PMID: 23294501

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Dataset Information

Comparative gene expression analysis of mesenchymal stem cells (MSC) derived from non-small cell lung cancer (NSCLC) and corresponding normal lung tissue (NLT)

Publications

Mesenchymal stem cells in non-small cell lung cancer--different from others? Insights from comparative molecular and functional analyses.

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