Ontology highlight
ABSTRACT:
ORGANISM(S): Xenopus laevis
SUBMITTER: Esther Pearl
PROVIDER: E-GEOD-23642 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Developmental biology 20110104 1
Mutations in rfx6 were recently associated with Mitchell-Riley syndrome, which involves neonatal diabetes, and other digestive system defects. To better define the function of Rfx6 in early endoderm development we cloned the Xenopus homologue. Expression of rfx6 begins early, showing broad expression throughout the anterior endoderm; at later stages rfx6 expression becomes restricted to the endocrine cells of the gut and pancreas. Morpholino knockdown of rfx6 caused a loss of pancreas marker exp ...[more]