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Study the role of miRNAs in metastasis progression of RCC cell lines

ABSTRACT: This study investigates for the miRNAs that drive or regulates Renal Cell Carcinoma (RCC) metastatic progression using two different RCC cell lines, the metastatic (LM2 and LM1) and non-metastatic (SN12C). The experiment is designed with three RCC cell lines one non-metastatic (SN12C) and two metastatic (LM1 and LM2). Each cell line has two biological replicates (exception SN12C has 3 replicates)

ORGANISM(S): Homo sapiens

SUBMITTER: Venkata Thodima

PROVIDER: E-GEOD-23690 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Genomic deregulation during metastasis of renal cell carcinoma implements a myofibroblast-like program of gene expression.

López-Lago Miguel A MA Thodima Venkata J VJ Guttapalli Asha A Chan Timothy T Heguy Adriana A Molina Ana M AM Reuter Victor E VE Motzer Robert J RJ Chaganti Raju S K RS

Cancer research 20101015 23

Clear cell renal cell carcinoma (RCC) is the most common and invasive adult kidney cancer. The genetic and biological mechanisms that drive metastatic spread of RCC remain largely unknown. We have investigated the molecular signatures and underlying genomic aberrations associated with RCC metastasis, using an approach that combines a human xenograft model; expression profiling of RNA, DNA, and microRNA (miRNA); functional verification; and clinical validation. We show that increased metastatic a ...[more]

PMID: 20952505

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