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A microRNA regulon that mediates endothelial recruitment by metastatic human breast cancer cells.

ABSTRACT: This SuperSeries is composed of the following subset Series: GSE23904: Gene expression profilling of poorly metastatic MDA cells and highly metastatic LM2 cells. GSE23905: miR-126 over-expression in highly metastatic LM2 breast cancer cells. Refer to individual Series

ORGANISM(S): Homo sapiens

SUBMITTER: Nils Halberg

PROVIDER: E-GEOD-23921 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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A microRNA regulon that mediates endothelial recruitment and metastasis by cancer cells.

Png Kim J KJ Halberg Nils N Yoshida Mitsukuni M Tavazoie Sohail F SF

Nature 20111214 7380

Metastatic progression of cancer is a complex and clinically daunting process. We previously identified a set of human microRNAs (miRNAs) that robustly suppress breast cancer metastasis to lung and bone and which display expression levels that predict human metastasis. Although these findings revealed miRNAs as suppressors of cell-autonomous metastatic phenotypes, the roles of non-coding RNAs in non-cell-autonomous cancer progression processes remain unknown. Here we reveal that endogenous miR-1 ...[more]

PMID: 22170610

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miR-126 over-expression in highly metastatic LM2 breast cancer cells.

Project description:miR-126 were over-expressed using the miR-Vec system in highly metastatic LM2 cells. The LM2 cell line are described in detail in Minn et al. Nature 2005 This approach was used to conduct an unbiased search for specific miR-126 target genes in breast cancer cells. 4 Samples

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