Unknown,Transcriptomics,Genomics,Proteomics

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HOP homeobox (Hopx) and Histone deacetylase-2 (Hdac2) deficiency effect on the embryonic heart


ABSTRACT: Analysis of heart ventricles from Hopx, Hdac2, and both Hopx-Hdac2 deficient embryos at embryonic day E16.5. Results provide insight into the role of Hopx and Hdac2 in cardiac development. We used microarrays to detail the global programme of gene expression underlying cardiac development by Hopx and Hdac2 and identified distinct classes of up-regulated and down-regulated genes during this process. Mouse embryonic ventricles were selected at E16.5 for RNA extraction and hybridization on Affymetrix microarrays. We obtained three independent embryonic ventricles for WT, Hopx-null, Hdac2-null, and Hopx-Hdac2 double null genotypes.

ORGANISM(S): Mus musculus

SUBMITTER: Jonathan Epstein 

PROVIDER: E-GEOD-23700 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Hopx and Hdac2 interact to modulate Gata4 acetylation and embryonic cardiac myocyte proliferation.

Trivedi Chinmay M CM   Zhu Wenting W   Wang Qiaohong Q   Jia Cheng C   Kee Hae Jin HJ   Li Li L   Hannenhalli Sridhar S   Epstein Jonathan A JA  

Developmental cell 20100901 3


Regulation of chromatin structure via histone modification has recently received intense attention. Here, we demonstrate that the chromatin-modifying enzyme histone deacetylase 2 (Hdac2) functions with a small homeodomain factor, Hopx, to mediate deacetylation of Gata4, which is expressed by cardiac progenitor cells and plays critical roles in the regulation of cardiogenesis. In the absence of Hopx and Hdac2 in mouse embryos, Gata4 hyperacetylation is associated with a marked increase in cardiac  ...[more]

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