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Transcription profiling of mouse HDAC2 knockout myocardium

ABSTRACT: We used microarrays to detail the global programme of gene expression underlying cardiac development by HDAC2 and identified distinct classes of up-regulated and down-regulated genes during this process. Experiment Overall Design: Embryonic heart ventricles were dissected at E17.5 for RNA extraction and hybridization on Affymetrix microarrays. Wild type and HDAC2-deficient littermates were used. Tissue from 2-3 individual animals of identical genotype was pooled for each micro-array.

ORGANISM(S): Mus musculus

SUBMITTER: Jonathan Epstein

PROVIDER: E-GEOD-6770 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Hdac2 regulates the cardiac hypertrophic response by modulating Gsk3 beta activity.

Trivedi Chinmay M CM Luo Yang Y Yin Zhan Z Zhang Maozhen M Zhu Wenting W Wang Tao T Floss Thomas T Goettlicher Martin M Noppinger Patricia Ruiz PR Wurst Wolfgang W Ferrari Victor A VA Abrams Charles S CS Gruber Peter J PJ Epstein Jonathan A JA

Nature medicine 20070218 3

In the adult heart, a variety of stresses induce re-expression of a fetal gene program in association with myocyte hypertrophy and heart failure. Here we show that histone deacetylase-2 (Hdac2) regulates expression of many fetal cardiac isoforms. Hdac2 deficiency or chemical histone deacetylase (HDAC) inhibition prevented the re-expression of fetal genes and attenuated cardiac hypertrophy in hearts exposed to hypertrophic stimuli. Resistance to hypertrophy was associated with increased expressio ...[more]

PMID: 17322895

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Expression data from primary MEF lacking either HDAC1, HDAC2 or both

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Functions of HDAC1 and HDAC2 in Schwann cells during postnatal

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