Unknown,Transcriptomics,Genomics,Proteomics

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Adult epidermal Notch activity induces dermal accumulation of stromal cells

ABSTRACT: K14NICDER transgenic and wildtype littermate mice were treated with 4OHT for 14 days to activate the transgene Epidermis and dermis preparations from Transgenic and Wild type mice plus whole skin We sought to compare gene expression patterns in K14NICDER transgenic epidermis and dermis to wild type controls

ORGANISM(S): Mus musculus

SUBMITTER: Carrie Ambler

PROVIDER: E-GEOD-23782 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Adult epidermal Notch activity induces dermal accumulation of T cells and neural crest derivatives through upregulation of jagged 1.

Ambler Carrie A CA Watt Fiona M FM

Development (Cambridge, England) 20101101 21

Notch signalling regulates epidermal differentiation and tumour formation via non-cell autonomous mechanisms that are incompletely understood. This study shows that epidermal Notch activation via a 4-hydroxy-tamoxifen-inducible transgene caused epidermal thickening, focal detachment from the underlying dermis and hair clumping. In addition, there was dermal accumulation of T lymphocytes and stromal cells, some of which localised to the blisters at the epidermal-dermal boundary. The T cell infilt ...[more]

PMID: 20940224

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Dataset Information

Adult epidermal Notch activity induces dermal accumulation of stromal cells

Publications

Adult epidermal Notch activity induces dermal accumulation of T cells and neural crest derivatives through upregulation of jagged 1.

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