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Histone H3K27ac separates active from poised enhancers and predicts developmental state (gene expression data)

ABSTRACT: Developmental programs are controlled by transcription factors and chromatin regulators, which maintain specific gene expression programs through epigenetic modification of the genome. These regulatory events at enhancers contribute to the specific gene expression programs that determine cell state and the potential for differentiation into new cell types. While enhancer elements are known to be associated with certain histone modifications, and transcription factors, the relationship of these modifications to gene expression and developmental state has not been clearly defined. Here we interrogate the epigenetic landscape of enhancer elements in embryonic stem cells and several adult tissues in the mouse. We find that histone H3K27ac distinguishes active enhancers from inactive/poised enhancer elements, thus providing clues to current cell state and further developmental potential. Gene expression profiling was performed in mouse ES, NPC, liver, and pro-B

ORGANISM(S): Mus musculus

SUBMITTER: Menno Creyghton

PROVIDER: E-GEOD-23907 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Histone H3K27ac separates active from poised enhancers and predicts developmental state

Project description:This SuperSeries is composed of the following subset Series: GSE23907: Histone H3K27ac separates active from poised enhancers and predicts developmental state (gene expression data) GSE24164: ChIP-Seq of chromatin marks at distal enhancers in Mouse Embryonic Stem Cells and adult tissues. Refer to individual Series

2010-10-31 | E-GEOD-24165 | biostudies-arrayexpress

Histone H3K27ac separates active from poised enhancers and predicts developmental state (gene expression data)

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Master Transcription Factors and Mediator Establish Super-Enhancers at Key Cell Identity Genes

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2013-01-02 | E-GEOD-42474 | biostudies-arrayexpress

Master Transcription Factors and Mediator Establish Super-Enhancers at Key Cell Identity Genes [gene expression]

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Enhancer-core promoter specificity separates developmental and housekeeping regulation

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