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Transcription profiling time series of human RKO cell line responses to 2-hydroxy-2-nonenal

ABSTRACT: Cellular responses to 4-hydroxy-2-nonenal (HNE)--dose response and time course--three replicate experiments for each treatment

ORGANISM(S): Homo sapiens

SUBMITTER: James Daryl West

PROVIDER: E-GEOD-2397 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Alterations in gene expression induced by the lipid peroxidation product, 4-hydroxy-2-nonenal.

West James D JD Marnett Lawrence J LJ

Chemical research in toxicology 20051101 11

Reactive intermediates produced during oxidative stress are believed to contribute to the development and progression of a variety of age-related diseases. 4-hydroxy-2-nonenal (HNE), an abundant product of polyunsaturated fatty acid oxidation and decomposition, reacts extensively with DNA and proteins, depletes intracellular glutathione, and alters many cell signaling cascades, including those regulating apoptosis. Using microarray technology, global changes in gene expression were monitored tem ...[more]

PMID: 16300372

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