Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

LJMJDW: Cellular responses to 4-hydroxy-2-nonenal

ABSTRACT: Cellular responses to 4-hydroxy-2-nonenal (HNE)--dose response and time course--three replicate experiments for each treatment Keywords: other

ORGANISM(S): Homo sapiens

PROVIDER: GSE2397 | GEO | 2005/12/01

SECONDARY ACCESSION(S): PRJNA91599

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

Transcription profiling time series of human RKO cell line responses to 2-hydroxy-2-nonenal

Project description:Cellular responses to 4-hydroxy-2-nonenal (HNE)--dose response and time course--three replicate experiments for each treatment

2007-08-25 | E-GEOD-2397 | biostudies-arrayexpress

4-hydroxy-2-nonenal (4-HNE) induced transcriptional changes in Listeria monocytogenes

Project description:Pathogens must counteract a wide array of antimicrobial responses, including the reactive oxygen species (ROS) burst. ROS mediated oxidation of host membrane poly-unsaturated fatty acids (PUFAs) leads to the production of the toxic alpha-beta carbonyl 4-hydroxy-2-nonenal (4-HNE). 4-HNE has been studied extensively in the context of sterile inflammation but understanding of its role during bacterial infection remains limited. In this work we found that 4-HNE is generated during bacterial infection and that the intracellular pathogen Listeria monocytogenes induces a specific set of genes in response to 4-HNE exposure.

2020-05-10 | GSE150188 | GEO

Gene expression changes of 4-hydroxy-m-phenylenediammonium dichloride-induced in renal cortex of rats

Project description:This study is to develop a short term and highly accurate prediction method of renal carcinogenicity based on gene expression profile of rats administrated by carcinogens. We conducted 28 days-repeated dose experiments in male SD rats with 4-hydroxy-m-phenylenediammonium dichloride, and the gene expression profiles of renal cortex were analyzed using custom microarrays.

2016-09-27 | GSE87243 | GEO

4-hydroxy-2-nonenal (4-HNE) induced transcriptional changes in Listeria monocytogenes

Project description:4-hydroxy-2-nonenal (4-HNE) induced transcriptional changes in Listeria monocytogenes

| PRJNA631421 | ENA

Time course microarray data following GR activation in MCF10A-Myc breast cells

Project description:This series contain time course microarray data from MCF10A-Myc cells treated with either ethanol or Dexamethasone for 30 min, 2 hr, 4 hr, and 24 hr. This series contains three biological replicates that were analyzed as independent replicate experiments (data were normalized within each replicate experiment, not across all samples). Keywords: time course

2006-06-02 | GSE4917 | GEO

TET1-mediated DNA hydroxy-methylation regulates adult remyelination

Project description:Adult myelination is essential for brain function and response to injury, but the molecular mechanisms remain elusive. Here we identify DNA hydroxy-methylation, an epigenetic mark catalyzed by Ten-Eleven translocation (TET) enzymes, as necessary for adult myelin repair. While DNA hydroxy-methylation and high levels of TET1 were detected in young adult mice during myelin regeneration after demyelination, this process was defective in old mice. Constitutive or inducible lineage-specific ablation of Tet1 (but not of Tet2) recapitulated the age-related decline of DNA hydroxy-methylation and inefficient remyelination. Genome-wide hydroxy-methylation and transcriptomic analysis identified solute carrier gene families as TET1 targets. Lower transcripts for these genes in Tet1 mutants and old mice were associated with swelling at the neuroglial interface, a phenotype detected also in zebrafish Slc12a2b mutants. We conclude that TET1-mediated DNA hydroxy-methylation is necessary for adult myelination after injury, by modulating the levels of the solute carrier SLC12A2 at the axo-myelin interface.

2020-03-14 | GSE137611 | GEO

hGSTA4-4 transfection in HLE B-3 experiment

Project description:HLE B-3 cells were transfected with either empty vector or hGSTA4-4 expressing vector to lower intracellular 4-hydroxynonenal levels. hGSTA4-transfected sample has lower HNE levels than pTarget-transfected sample. Keywords = HNE hGSTA4 Keywords = 4-hydroxynonenal Keywords: dose response

2005-07-20 | GSE2298 | GEO

Early N-hydroxy-pipecolic acid transcriptional profile

Project description:Early N-hydroxy-pipecolic acid transcriptional profile

| PRJNA1096619 | ENA

Age-dependent decline of TET1-mediated DNA hydroxy-methylation impairs myelin regeneration after injury

Project description:Adult myelination is recognized as essential for brain function and response to injury and yet, its molecular understanding is mostly inferred from developmental studies. In this study, we identify DNA hydroxy-methylation, an epigenetic mark catalyzed by Ten-Eleven translocation (TET) enzymes, as necessary for adult, but not for developmental, myelin formation. While hydroxy-methylation and high levels of TET1 were detected in young adult mice during myelin regeneration after lysolecithin-induced demyelination, this process was defective in older mice. Lineage specific ablation of the enzyme Tet1 (but not of Tet2) recapitulated the age-related decline of TET1 and inefficient remyelination, without impacting developmental myelination. Genome-wide DNA hydroxy-methylation profiling of adult progenitors and mature oligodendrocytes, identified solute carriers regulating neuronal-glial communication as gene targets, whose expression was dramatically decreased in mutants and in older mice. We conclude that TET1-mediated hydroxy-methylation is critical for adult myelination in response to injury.

2020-03-14 | GSE122446 | GEO

DNA hydroxy-methylation data of tumor and non-tumor liver (NTL) tissues from Peruvian patients with hepatocellular carcinoma (HCC)

Project description:A large fraction of HCC in Peru arises in younger, non-cirrhotic patients. Global DNA hydroxy-methylation analysis of the HCC and NTL tissues demonstrate that hydroxy-methylation conversion interplays with gene expression to enact cell fate determination and cancer cell reprogramming. We used microarrays to identify hydroxy-methylated CpGs by comparison to Gene Expression Omnibus (GEO) series GSE136319 and GSE136380.

2021-01-31 | GSE136583 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data