Unknown,Transcriptomics,Genomics,Proteomics

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Affymetrix SNP array data for oral squamous cell carcinoma


ABSTRACT: In order to identify biomarkers that contribute to genetic causes of OSCC, we attempt to identify copy number variation regions (CNV) in patients with OSCC. We identified and confirmed the clinical significance of amplification regions scattered from 8q22.2 to 8q24.3. Affymetrix SNP arrays were performed according to the manufacturer's directions on DNA extracted from normal oral tissues and OSCC specimens. Copy number analysis of Affymetrix SNP 6.0 arrays was performed for 112 OSCC specimens and 10 non-cancerous samples.

ORGANISM(S): Homo sapiens

SUBMITTER: Chien-Hua Peng 

PROVIDER: E-GEOD-25103 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

A novel molecular signature identified by systems genetics approach predicts prognosis in oral squamous cell carcinoma.

Peng Chien-Hua CH   Liao Chun-Ta CT   Peng Shih-Chi SC   Chen Yin-Ju YJ   Cheng Ann-Joy AJ   Juang Jyh-Lyh JL   Tsai Chi-Ying CY   Chen Tse-Ching TC   Chuang Yung-Jen YJ   Tang Chuan-Yi CY   Hsieh Wen-Ping WP   Yen Tzu-Chen TC  

PloS one 20110811 8


Molecular methods for predicting prognosis in patients with oral cavity squamous cell carcinoma (OSCC) are urgently needed, considering its high recurrence rate and tendency for metastasis. The present study investigated the genetic basis of variations in gene expression associated with poor prognosis in OSCC using Affymetrix SNP 6.0 and Affymetrix GeneChip Human Gene 1.0 ST arrays. We identified recurrent DNA amplifications scattered from 8q22.2 to 8q24.3 in 112 OSCC specimens. These amplicons  ...[more]

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