Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of mouse conditional knock out of beta-catenin by K19-CRE at E7.5


ABSTRACT: expression profile of conditional knock out of beta-catenin by K19-CRE at E7.5. Tested a wild type with two alleles of beta-catenin, a heterzyote with one deleted allele and the conditional null in the domain on cytokeratin 19 driven CRE expression

ORGANISM(S): Mus musculus

SUBMITTER: Brian Cox 

PROVIDER: E-GEOD-2519 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Dissecting Wnt/beta-catenin signaling during gastrulation using RNA interference in mouse embryos.

Lickert Heiko H   Cox Brian B   Wehrle Christian C   Taketo Makoto M MM   Kemler Rolf R   Rossant Janet J  

Development (Cambridge, England) 20050427 11


Differential gene regulation integrated in time and space drives developmental programs during embryogenesis. To understand how the program of gastrulation is regulated by Wnt/beta-catenin signaling, we have used genome-wide expression profiling of conditional beta-catenin mutant embryos. Known Wnt/beta-catenin target genes, known components of other signaling pathways, as well as a number of uncharacterized genes were downregulated in these mutants. To further narrow down the set of differentia  ...[more]

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