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Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of mouse liver in conditional knockouts of the tumor suppressor gene Apc identifies Wnt/bet-catenin signaling activation in hepatocytes

ABSTRACT: A "Cartes d'Identite des Tumeurs" (CIT) project from the french Ligue Nationale Contre le Cancer (http://cit.ligue-cancer.net). Conditional Knockout mouse model for the tumor suppressor gene Ap, Apc 2lox. The disruption of the Apc gene is realized by injection of an adenovirus encoding the Cre recombinase (AdCre). Homozygous animals injected with a high dose of AdCre showed an activation of the Wnt/beta-catenin signaling in most of the hepatocytes and develop an hepatomegaly and die soon after. Analysis of gene up- and down regulation for liver-indicible APC disruption.

ORGANISM(S): Mus musculus

DISEASE(S): hepatomegaly

SUBMITTER: Mireille Vasseur-Cognet

PROVIDER: E-TABM-81 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Apc tumor suppressor gene is the "zonation-keeper" of mouse liver.

Benhamouche Samira S Decaens Thomas T Godard Cécile C Chambrey Régine R Rickman David S DS Moinard Christophe C Vasseur-Cognet Mireille M Kuo Calvin J CJ Kahn Axel A Perret Christine C Colnot Sabine S

Developmental cell 20060601 6

The molecular mechanisms by which liver genes are differentially expressed along a portocentral axis, allowing for metabolic zonation, are poorly understood. We provide here compelling evidence that the Wnt/beta-catenin pathway plays a key role in liver zonation. First, we show the complementary localization of activated beta-catenin in the perivenous area and the negative regulator Apc in periportal hepatocytes. We then analyzed the immediate consequences of either a liver-inducible Apc disrupt ...[more]

PMID: 16740478

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Transcription profiling of mouse intestinal polyps from Apc Delta14 strain treated with parecoxib

Project description:A "Cartes d'Identite des Tumeurs" (CIT) project from the french Ligue Nationale Contre le Cancer (http://cit.ligue-cancer.net). Comparison of mouse intestinal polyps response to parecoxib with controls.

2009-05-31 | E-MEXP-2156 | biostudies-arrayexpress

Transcription profiling of liver from wild type and tumor suppressor Apc knock-out mice

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Transcription profiling by array of human HT29 colorectal cells treated with eicosapentaenoic acid

Project description:Effects of eicosapentaenoic acid on gene expression profiles in HT29 human colorectal cells

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Chromatin immunoprecipitation of the MSL-1 and MSL-3 vs a mock IP in Drosophila and transcription profiling of X linked genes in WT male or female III instar larvae to provide X chromosome wide profiling of MSL-1 distribution and dosage compensation in Drosophila

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2008-06-30 | E-MEXP-794 | biostudies-arrayexpress

Transcription profiling of Baseline gene expression in circulating peripheral blood mononuclear cells isolated from 18 apparently healthy volunteers (10 females and 8 males)

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2013-01-30 | E-TABM-7 | biostudies-arrayexpress

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