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Adipose Tissue MicroRNAs as Regulators of CCL2 Production in Human Obesity

ABSTRACT: This SuperSeries is composed of the following subset Series: GSE25401: Adipose Tissue MicroRNAs as Regulators of CCL2 Production in Human Obesity [gene expression] GSE25470: Adipose Tissue MicroRNAs as Regulators of CCL2 Production in Human Obesity [miRNA data] GSE25910: Adipose Tissue MicroRNAs as Regulators of CCL2 Production in Human Obesity [differentiation data] Refer to individual Series

ORGANISM(S): Homo sapiens

SUBMITTER: Ingrid Dahlman

PROVIDER: E-GEOD-25402 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Adipose tissue microRNAs as regulators of CCL2 production in human obesity.

Arner Erik E Mejhert Niklas N Kulyté Agné A Balwierz Piotr J PJ Pachkov Mikhail M Cormont Mireille M Lorente-Cebrián Silvia S Ehrlund Anna A Laurencikiene Jurga J Hedén Per P Dahlman-Wright Karin K Tanti Jean-François JF Hayashizaki Yoshihide Y Rydén Mikael M Dahlman Ingrid I van Nimwegen Erik E Daub Carsten O CO Arner Peter P

Diabetes 20120611 8

In obesity, white adipose tissue (WAT) inflammation is linked to insulin resistance. Increased adipocyte chemokine (C-C motif) ligand 2 (CCL2) secretion may initiate adipose inflammation by attracting the migration of inflammatory cells into the tissue. Using an unbiased approach, we identified adipose microRNAs (miRNAs) that are dysregulated in human obesity and assessed their possible role in controlling CCL2 production. In subcutaneous WAT obtained from 56 subjects, 11 miRNAs were present in ...[more]

PMID: 22688341

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