The effect of progressive weight loss on metabolic function
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Jun Yoshino
PROVIDER: E-GEOD-70529 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Effects of Moderate and Subsequent Progressive Weight Loss on Metabolic Function and Adipose Tissue Biology in Humans with Obesity.
Magkos Faidon F Fraterrigo Gemma G Yoshino Jun J Luecking Courtney C Kirbach Kyleigh K Kelly Shannon C SC de las Fuentes Lisa L He Songbing S Okunade Adewole L AL Patterson Bruce W BW Klein Samuel S
Cell metabolism 20160222 4
Although 5%-10% weight loss is routinely recommended for people with obesity, the precise effects of 5% and further weight loss on metabolic health are unclear. We conducted a randomized controlled trial that evaluated the effects of 5.1% ± 0.9% (n = 19), 10.8% ± 1.3% (n = 9), and 16.4% ± 2.1% (n = 9) weight loss and weight maintenance (n = 14) on metabolic outcomes. 5% weight loss improved adipose tissue, liver and muscle insulin sensitivity, and β cell function, without a concomitant change in ...[more]
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