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The effects of moderate weight gain in adipose tissue gene expression in metabolically-normal (MNO) and metabolically-abnormal (MAO) subjects

ABSTRACT: Obesity is associated with insulin resistance and increased intrahepatic triglyceride (IHTG) content, which are key risk factors for diabetes and cardiovascular disease. However, a subset of obese people does not develop these metabolic complications. We tested the hypothesis that MNO, but not MAO, people are protected from the adverse metabolic effects of weight gain. To this end, global transcriptional profile in adipose tissue before and after weight gain was evaluated by microarray analyses. We collected subcutaneous adipose tissue samples from MNO (n=11) and MAO (n=7) subjects before and after moderate (~6%) weight gain (total 36 samples). We evaluated the effects of weight gain on adipose tissue gene expression in both MNO and MNO subjects.We used the GeneChip Human Gene 1.0 ST array (Affymetrix, Santa Clara, CA, USA).

ORGANISM(S): Homo sapiens

SUBMITTER: Jun Yoshino 

PROVIDER: E-GEOD-62832 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Metabolically normal obese people are protected from adverse effects following weight gain.

Fabbrini Elisa E   Yoshino Jun J   Yoshino Mihoko M   Magkos Faidon F   Tiemann Luecking Courtney C   Samovski Dmitri D   Fraterrigo Gemma G   Okunade Adewole L AL   Patterson Bruce W BW   Klein Samuel S  

The Journal of clinical investigation 20150102 2

BACKGROUND. Obesity is associated with insulin resistance and increased intrahepatic triglyceride (IHTG) content, both of which are key risk factors for diabetes and cardiovascular disease. However, a subset of obese people does not develop these metabolic complications. Here, we tested the hypothesis that people defined by IHTG content and insulin sensitivity as "metabolically normal obese" (MNO), but not those defined as "metabolically abnormal obese" (MAO), are protected from the adverse meta  ...[more]

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