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Comparison of the expression profiles of 630E strain and a sigH mutant after 10h of growth

ABSTRACT: Transcriptionnal profiling of C. difficile 630E strain vs a sigH mutant after 10h of growth in TY Two-conditions experiments, 630E strain 10h vs sigH mutant 10h, 4 biological replicates for each condition

ORGANISM(S): [Clostridium] difficile

SUBMITTER: Monot Marc 

PROVIDER: E-GEOD-25475 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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The key sigma factor of transition phase, SigH, controls sporulation, metabolism, and virulence factor expression in Clostridium difficile.

Saujet Laure L   Monot Marc M   Dupuy Bruno B   Soutourina Olga O   Martin-Verstraete Isabelle I  

Journal of bacteriology 20110513 13

Toxin synthesis in Clostridium difficile increases as cells enter into stationary phase. We first compared the expression profiles of strain 630E during exponential growth and at the onset of stationary phase and showed that genes involved in sporulation, cellular division, and motility, as well as carbon and amino acid metabolism, were differentially expressed under these conditions. We inactivated the sigH gene, which encodes an alternative sigma factor involved in the transition to post-expon  ...[more]

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