Ontology highlight
ABSTRACT:
ORGANISM(S): [Clostridium] difficile
SUBMITTER: Monot Marc
PROVIDER: E-GEOD-35070 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Nucleic acids research 20120918 21
The catabolite control protein CcpA is a pleiotropic regulator that mediates the global transcriptional response to rapidly catabolizable carbohydrates, like glucose in Gram-positive bacteria. By whole transcriptome analyses, we characterized glucose-dependent and CcpA-dependent gene regulation in Clostridium difficile. About 18% of all C. difficile genes are regulated by glucose, for which 50% depend on CcpA for regulation. The CcpA regulon comprises genes involved in sugar uptake, fermentation ...[more]