Underreplication
Ontology highlight
ABSTRACT:
ORGANISM(S): Drosophila melanogaster
SUBMITTER: Igor Zhimulev
PROVIDER: E-GEOD-2551 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Genomic analysis of Drosophila chromosome underreplication reveals a link between replication control and transcriptional territories.
Belyakin Stepan N SN Christophides George K GK Alekseyenko Artyom A AA Kriventseva Evgenia V EV Belyaeva Elena S ES Nanayev Roman A RA Makunin Igor V IV Kafatos Fotis C FC Zhimulev Igor F IF
Proceedings of the National Academy of Sciences of the United States of America 20050531 23
In Drosophila polytene chromosomes, most late-replicating regions remain underreplicated. A loss-of-function mutant of the suppressor of underreplication [Su(UR)] gene suppresses underreplication (UR), whereas extra copies of this gene enhance the level and number of regions showing UR. By combining DNA microarray analysis with manipulation of the number of Su(UR) gene copies, we achieved genomic-scale molecular identification of 1,036 genes that are arranged in clusters located in 52 UR chromos ...[more]
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