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Paternally-induced transgenerational environmental reprogramming of metabolic gene expression in mammals (small RNA)

ABSTRACT: Characterized the small (19-35 bp) RNA population from control and low protein offspring livers by high throughput sequencing. Eight sequencing lanes, one for each animal, with an average of 3.7 million mappable reads per lane. A number of miRNAs changed expression in the offspring from low protein diet fathers. Examination of the effect of 2 different paternal diets, control diet and low-protein diet, on the small RNA expression in the liver of the offsprings. 8 samples: 4 are control diets and 4 are low protein diets

ORGANISM(S): Mus musculus

SUBMITTER: naomi habib

PROVIDER: E-GEOD-25897 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Paternally induced transgenerational environmental reprogramming of metabolic gene expression in mammals.

Carone Benjamin R BR Fauquier Lucas L Habib Naomi N Shea Jeremy M JM Hart Caroline E CE Li Ruowang R Bock Christoph C Li Chengjian C Gu Hongcang H Zamore Phillip D PD Meissner Alexander A Weng Zhiping Z Hofmann Hans A HA Friedman Nir N Rando Oliver J OJ

Cell 20101201 7

Epigenetic information can be inherited through the mammalian germline and represents a plausible transgenerational carrier of environmental information. To test whether transgenerational inheritance of environmental information occurs in mammals, we carried out an expression profiling screen for genes in mice that responded to paternal diet. Offspring of males fed a low-protein diet exhibited elevated hepatic expression of many genes involved in lipid and cholesterol biosynthesis and decreased ...[more]

PMID: 21183072

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Paternally-induced transgenerational environmental reprogramming of metabolic gene expression in mammals

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