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Paternally-induced transgenerational environmental reprogramming of metabolic gene expression in mammals

ABSTRACT: This SuperSeries is composed of the following subset Series: GSE25895: Paternally-induced transgenerational environmental reprogramming of metabolic gene expression in mammals (dye swap) GSE25896: Paternally-induced transgenerational environmental reprogramming of metabolic gene expression in mammals (Affymetrix) GSE25897: Paternally-induced transgenerational environmental reprogramming of metabolic gene expression in mammals (small RNA) GSE25898: Paternally-induced transgenerational environmental reprogramming of metabolic gene expression in mammals (meDIP) Refer to individual Series

ORGANISM(S): Mus musculus

SUBMITTER: naomi habib

PROVIDER: E-GEOD-25899 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Paternally induced transgenerational environmental reprogramming of metabolic gene expression in mammals.

Carone Benjamin R BR Fauquier Lucas L Habib Naomi N Shea Jeremy M JM Hart Caroline E CE Li Ruowang R Bock Christoph C Li Chengjian C Gu Hongcang H Zamore Phillip D PD Meissner Alexander A Weng Zhiping Z Hofmann Hans A HA Friedman Nir N Rando Oliver J OJ

Cell 20101201 7

Epigenetic information can be inherited through the mammalian germline and represents a plausible transgenerational carrier of environmental information. To test whether transgenerational inheritance of environmental information occurs in mammals, we carried out an expression profiling screen for genes in mice that responded to paternal diet. Offspring of males fed a low-protein diet exhibited elevated hepatic expression of many genes involved in lipid and cholesterol biosynthesis and decreased ...[more]

PMID: 21183072

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