Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: raffaella meneveri
PROVIDER: E-GEOD-26061 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Cheli Stefania S François Stephanie S Bodega Beatrice B Ferrari Francesco F Tenedini Elena E Roncaglia Enrica E Ferrari Sergio S Ginelli Enrico E Meneveri Raffaella R
PloS one 20110613 6
<h4>Background</h4>Determine global gene dysregulation affecting 4q-linked (FSHD-1) and non 4q-linked (FSHD-2) cells during early stages of myogenic differentiation. This approach has been never applied to FSHD pathogenesis.<h4>Methodology/principal findings</h4>By in vitro differentiation of FSHD-1 and FSHD-2 myoblasts and gene chip analysis we derived that gene expression profile is altered only in FSHD-1 myoblasts and FSHD-2 myotubes. The changes seen in FSHD-1 regarded a general defect in ce ...[more]