Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Matthew Murray
PROVIDER: E-GEOD-26175 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Muralidhar Balaji B Winder David D Murray Matthew M Palmer Roger R Barbosa-Morais Nuno N Saini Harpreet H Roberts Ian I Pett Mark M Coleman Nicholas N
The Journal of pathology 20110518 4
Although gain of chromosome 5p is one of the most frequent DNA copy-number imbalances in cervical squamous cell carcinoma (SCC), the genes that drive its selection remain poorly understood. In a previous cross-sectional clinical study, we showed that the microRNA processor Drosha (located on chromosome 5p) demonstrates frequent copy-number gain and overexpression in cervical SCC, associated with altered microRNA profiles. Here, we have conducted gene depletion/overexpression experiments to demon ...[more]