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Pivotal role of HMGA1 gene signature in highly metastatic breast cancer

ABSTRACT: Analysis of MDA-MB-231 breast cancer cells depleted for High Mobility Group A1 (HMGA1) using siRNA. HMGA1 is involved in invasion and metastasis in breast cancer cells. Results identify the specific transcriptional program induced by HMGA1 in highly metastatic breast cancer cells. MDA-MB-231 cells were transfected with HMGA1-specific siRNA or a control siRNA. Transfections were performed by using Lipofectamin RNAiMAX (Invitrogen) according to the manufacturer's procedure. Seventy-two hours after transfection, samples were processed for total RNA extraction and hybridization on Affymetrix microarrays. Four biological replicas (A, B, C, D) were used for each of the two conditions, for a total of 8 samples.

ORGANISM(S): Homo sapiens

SUBMITTER: Silvano Piazza 

PROVIDER: E-GEOD-35525 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

HMGA1 promotes metastatic processes in basal-like breast cancer regulating EMT and stemness.

Pegoraro Silvia S   Ros Gloria G   Piazza Silvano S   Sommaggio Roberta R   Ciani Yari Y   Rosato Antonio A   Sgarra Riccardo R   Del Sal Giannino G   Manfioletti Guidalberto G  

Oncotarget 20130801 8

Breast cancer is a heterogeneous disease that progresses to the critical hallmark of metastasis. In the present study, we show that the High Mobility Group A1 (HMGA1) protein plays a fundamental role in this process in basal-like breast cancer subtype. HMGA1 knockdown induces the mesenchymal to epithelial transition and dramatically decreases stemness and self-renewal. Notably, HMGA1 depletion in basal-like breast cancer cell lines reduced migration and invasion in vitro and the formation of met  ...[more]

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