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E47 KO versus WT HSCs

ABSTRACT: Genome-wide gene expression pattern of E47 KO versus WT HSCs from primary and secondary recipient mice were analysis using Agilent one-color micro-array analysis. Two replicates from 4 samples are analyzed. The sample from the WT mouse were set as their reference sample.

ORGANISM(S): Mus musculus

SUBMITTER: Qi Yang

PROVIDER: E-GEOD-26788 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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E47 regulates hematopoietic stem cell proliferation and energetics but not myeloid lineage restriction.

Yang Qi Q Esplin Brandt B Borghesi Lisa L

Blood 20110127 13

The immune system is replenished by self-renewing hematopoietic stem cells (HSCs) that produce multipotent progenitors (MPPs) with little renewal capacity. E-proteins, the widely expressed basic helix-loop-helix transcription factors, contribute to HSC and MPP activity, but their specific functions remain undefined. Using quantitative in vivo and in vitro approaches, we show that E47 is dispensable for the short-term myeloid differentiation of HSCs but regulates their long-term capabilities. E47 ...[more]

PMID: 21273306

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