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Gene expression-based, individualized diagnostic GC/ABC prediction for relapse/refractory diffuse large B cell lymphoma (DLBCL)

ABSTRACT: Individualized diagnosis prediction classifiers were successfully constructed through expression profiling of a total of 8,644 genes in 49 patients with relapse/refractory diffuse large B cell lymphoma, prospectively treated in a randomized trial. keyword(s): Diagnosis prediction All lymphoma cases were predicted as belonging either to germical center B-cell like DLBCL or activated B cell like DLBCL based on the expression of a set of 54 genes (140 probes).

ORGANISM(S): Homo sapiens

SUBMITTER: Edouard Hirchaud 

PROVIDER: E-GEOD-26812 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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The germinal center/activated B-cell subclassification has a prognostic impact for response to salvage therapy in relapsed/refractory diffuse large B-cell lymphoma: a bio-CORAL study.

Thieblemont Catherine C   Briere Josette J   Mounier Nicolas N   Voelker Hans-Ullrich HU   Cuccuini Wendy W   Hirchaud Edouard E   Rosenwald Andreas A   Jack Andrew A   Sundstrom Christer C   Cogliatti Sergio S   Trougouboff Philippe P   Boudova Ludmila L   Ysebaert Loic L   Soulier Jean J   Chevalier Catherine C   Bron Dominique D   Schmitz Norbert N   Gaulard Philippe P   Houlgatte Remi R   Gisselbrecht Christian C  

Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20110926 31

<h4>Purpose</h4>To evaluate the prognostic value of the cell of origin (COO) in patients with relapsed/refractory diffuse large B-cell lymphoma (DLBLC), prospectively treated by rituximab, dexamethasone, high-dose cytarabine, and cisplatin (R-DHAP) versus rituximab, ifosfamide, carboplatin, and etoposide and followed by intensive therapy plus autologous stem-cell transplantation on the Collaborative Trial in Relapsed Aggressive Lymphoma (CORAL) trial.<h4>Patients and methods</h4>Among the 396 pa  ...[more]

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