Unknown,Transcriptomics,Genomics,Proteomics

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Top2β ChIP-chip


ABSTRACT: Chromatin IP was performed with Top2β antibodies in WT neurons and hybridized to custom designed tiling array. HD 2.1 (custom- made)

ORGANISM(S): Mus musculus

SUBMITTER: Dirk Schuebeler 

PROVIDER: E-GEOD-27246 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Target genes of Topoisomerase IIβ regulate neuronal survival and are defined by their chromatin state.

Tiwari Vijay K VK   Burger Lukas L   Nikoletopoulou Vassiliki V   Deogracias Ruben R   Thakurela Sudhir S   Wirbelauer Christiane C   Kaut Johannes J   Terranova Remi R   Hoerner Leslie L   Mielke Christian C   Boege Fritz F   Murr Rabih R   Peters Antoine H F M AH   Barde Yves-Alain YA   Schübeler Dirk D  

Proceedings of the National Academy of Sciences of the United States of America 20120402 16


Topoisomerases are essential for DNA replication in dividing cells, but their genomic targets and function in postmitotic cells remain poorly understood. Here we show that a switch in the expression from Topoisomerases IIα (Top2α) to IIβ (Top2β) occurs during neuronal differentiation in vitro and in vivo. Genome-scale location analysis in stem cell-derived postmitotic neurons reveals Top2β binding to chromosomal sites that are methylated at lysine 4 of histone H3, a feature of regulatory regions  ...[more]

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