Unknown,Transcriptomics,Genomics,Proteomics

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Topoisomerase IIbeta occupies H3K4 methylated sites and regulates neuronal survival via repression of the neurotrophin receptor p75


ABSTRACT: This SuperSeries is composed of the following subset Series: GSE27245: Expression data from Top2β KO cells as well ICRF-193 treatment of in vitro derived neurons and cortical glutamatergic neurons GSE27246: Top2β ChIP-chip Refer to individual Series

ORGANISM(S): Mus musculus

SUBMITTER: Dirk Schuebeler 

PROVIDER: E-GEOD-27247 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Target genes of Topoisomerase IIβ regulate neuronal survival and are defined by their chromatin state.

Tiwari Vijay K VK   Burger Lukas L   Nikoletopoulou Vassiliki V   Deogracias Ruben R   Thakurela Sudhir S   Wirbelauer Christiane C   Kaut Johannes J   Terranova Remi R   Hoerner Leslie L   Mielke Christian C   Boege Fritz F   Murr Rabih R   Peters Antoine H F M AH   Barde Yves-Alain YA   Schübeler Dirk D  

Proceedings of the National Academy of Sciences of the United States of America 20120402 16


Topoisomerases are essential for DNA replication in dividing cells, but their genomic targets and function in postmitotic cells remain poorly understood. Here we show that a switch in the expression from Topoisomerases IIα (Top2α) to IIβ (Top2β) occurs during neuronal differentiation in vitro and in vivo. Genome-scale location analysis in stem cell-derived postmitotic neurons reveals Top2β binding to chromosomal sites that are methylated at lysine 4 of histone H3, a feature of regulatory regions  ...[more]

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