Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

0

Comparison of gene expression profiles of normal human bronchial epithelial cells in 2D and 3D cultural conditions

ABSTRACT: The experiment is part of a project to study DNA repair process after ionizing radiation in organotypic 3-dimentional human bronchial epithlial cell culture. Human bronchial epithelial cells were grown in tissue culture flask (2D) or in matrics gel (3D). Three independent cultures were done for each condition.

ORGANISM(S): Homo sapiens

SUBMITTER: Lianghao Ding 

PROVIDER: E-GEOD-27520 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

Json Xml
altmetric image

Publications

Irreparable complex DNA double-strand breaks induce chromosome breakage in organotypic three-dimensional human lung epithelial cell culture.

Asaithamby Aroumougame A   Hu Burong B   Delgado Oliver O   Ding Liang-Hao LH   Story Michael D MD   Minna John D JD   Shay Jerry W JW   Chen David J DJ  

Nucleic acids research 20110318 13

DNA damage and consequent mutations initiate the multistep carcinogenic process. Differentiated cells have a reduced capacity to repair DNA lesions, but the biological impact of unrepaired DNA lesions in differentiated lung epithelial cells is unclear. Here, we used a novel organotypic human lung three-dimensional (3D) model to investigate the biological significance of unrepaired DNA lesions in differentiated lung epithelial cells. We showed, consistent with existing notions that the kinetics o  ...[more]

Similar Datasets

Transcriptomics Comparison of gene expression profiles of normal human bronchial epithelial cells in 2D and 3D cultural conditions
2011-07-27 | GSE27520 | GEO
Transcriptomics 3D vs . 2D culture of HUASMC
2019-12-16 | GSE133650 | GEO
Transcriptomics Expression data from Triple Negative Breast Cancer (TNBC) cell lines cultured in 2D and 3D.
2024-09-20 | GSE277405 | GEO
Genomics 3D vs . 2D culture of HUASMC
| PRJNA552084 | ENA
Clinical 3D Laparoscopy Versus 2D Laparoscopy
| 2220465 | ecrin-mdr-crc
Transcriptomics Expression data from MSCs cultured on 3D and 2D matrixes
2018-06-19 | GSE115947 | GEO
Transcriptomics HUVEC with/without VEGF-A treatment in 3D matrigel or 2D monoculture
2015-06-30 | E-GEOD-53550 | biostudies-arrayexpress
Transcriptomics Lung cell lines grown in 2D and 3D
2020-09-26 | GSE158597 | GEO
Transcriptomics FRT thyroid cells: 2D monolayers vs. 3D follicles
2016-11-24 | GSE71259 | GEO
Transcriptomics RNA-seq for MDCKII 3D and 2D epithelial morphogenesis.
2020-09-25 | GSE129823 | GEO