Unknown,Transcriptomics,Genomics,Proteomics

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Genome-wide analysis of gene expression patterns in mir-122 knockout mice livers


ABSTRACT: To invesigate the physiology roles of mir-122 in liver, we performed expression profiling of mir-122 knockout mice and the control B6/129 mice. Total RNA was extracted from four mir-122 knockout mice and three control mice of 2 months of age. Gene expression was quantified by robust multi-array analysis (RMA) using the Genomic Suite software from Partek.

ORGANISM(S): Mus musculus

SUBMITTER: Ann-Ping Tsou 

PROVIDER: E-GEOD-27713 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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MicroRNA-122 (miR-122), which accounts for 70% of the liver's total miRNAs, plays a pivotal role in the liver. However, its intrinsic physiological roles remain largely undetermined. We demonstrated that mice lacking the gene encoding miR-122a (Mir122a) are viable but develop temporally controlled steatohepatitis, fibrosis, and hepatocellular carcinoma (HCC). These mice exhibited a striking disparity in HCC incidence based on sex, with a male-to-female ratio of 3.9:1, which recapitulates the dis  ...[more]

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