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Human subcutaneous adipose tissue gene expression (SOS Sib-pair study, offspring cohort)

ABSTRACT: Obesity has considerable effects on morbidity and mortality, and the prevalence of obesity has been increasing rapidly worldwide during the past two decades. Even if obesity affects the entire individual, adipose tissue plays a central role in the development of obesity. Expression profiling of adipose tissue may give insights into the mechanisms contributing to obesity and obesity-related disorders. The Swedish Obese Subjects (SOS) Sib-Pair Study consists of 154 nuclear families with BMI-discordant sib pairs (BMI difference more than 10 kg/m2) resulting in a study population consisting of 732 subjects. The full SOS Sib-Pair study offspring cohort consists of 425 subjects. Microarray expression analysis in subcutaneous adipose tissue was performed in 375 subjects (262 women and 113 men) of the SOS Sib-Pair offspring cohort. Microarray expression analysis in subcutaneous adipose tissue was performed in women (n=262) and men (n=113) of the SOS Sib-Pair offspring cohort.

ORGANISM(S): Homo sapiens

SUBMITTER: Intawat Nookaew 

PROVIDER: E-GEOD-27916 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Adipose tissue resting energy expenditure and expression of genes involved in mitochondrial function are higher in women than in men.

Nookaew Intawat I   Svensson Per-Arne PA   Jacobson Peter P   Jernås Margareta M   Taube Magdalena M   Larsson Ingrid I   Andersson-Assarsson Johanna C JC   Sjöström Lars L   Froguel Philippe P   Walley Andrew A   Nielsen Jens J   Carlsson Lena M S LM  

The Journal of clinical endocrinology and metabolism 20121221 2

<h4>Context</h4>Men and women differ in body fat distribution and adipose tissue metabolism as well as in obesity comorbidities and their response to obesity treatment.<h4>Objective</h4>The objective of the study was a search for sex differences in adipose tissue function.<h4>Design and setting</h4>This was an exploratory study performed at a university hospital.<h4>Participants and main outcome measures</h4>Resting metabolic rate (RMR), body composition, and sc adipose tissue genome-wide expres  ...[more]

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