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Screening Hub Genes Related to the Recovery Phase of Irradiation Injury by Microarray Analysis Combined with Integrated Gene Network

ABSTRACT: Microarray analysis was used to identify the differentially expressed genes. Bioinformatics analyses integrated with databases and text-mined gene network were conducted to understand irradiation-related hub genes, pathways and biological processes. Our hypothesis in these paper are: 1) the expression profiles of irradiation damaged bone marrow tissue are not identical in injury phase and recovery phase; and 2) some hub genes potentially vital to BM recovery can be screened out by means of microarray analysis and bioinformatics analysis. The results provide basic information to explain the radiation-related biological processes and hub genes. The five mRNA samples in total bone marrow cells were profiled by using gene chip at 3, 7, 11 and 21 days after irradiation and 0 day (sham-irradiation) as control. Each time point contains one sample.

ORGANISM(S): Mus musculus

SUBMITTER: Ming Yin 

PROVIDER: E-GEOD-28195 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Identification of hub genes related to the recovery phase of irradiation injury by microarray and integrated gene network analysis.

Zhang Jing J   Yang Yue Y   Wang Yin Y   Zhang Jinyuan J   Wang Zejian Z   Yin Ming M   Shen Xudong X  

PloS one 20110913 9

<h4>Background</h4>Irradiation commonly causes long-term bone marrow injury charactertized by defective HSC self-renewal and a decrease in HSC reserve. However, the effect of high-dose IR on global gene expression during bone marrow recovery remains unknown.<h4>Methodology</h4>Microarray analysis was used to identify differentially expressed genes that are likely to be critical for bone marrow recovery. Multiple bioinformatics analyses were conducted to identify key hub genes, pathways and biolo  ...[more]

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