Dataset Information

Liquid chromatography-tandem mass spectrometry analysis of bone marrow from the ground or running rats

ABSTRACT: Exercise can prevent osteoporosis and improve immune function, but the mechanism remains unclear. To explore the key factors involved in these two processes, we collected bone marrow from ground and running rats and then conducted liquid chromatography-tandem mass spectrometry.

INSTRUMENT(S): Q Exactive HF

ORGANISM(S): Rattus Norvegicus (rat)

TISSUE(S): Bone Marrow

SUBMITTER: Hui Peng

LAB HEAD: Xianghang Luo

PROVIDER: PXD033807 | Pride | 2023-10-17

REPOSITORIES: Pride

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Publications

A mechanosensitive lipolytic factor in the bone marrow promotes osteogenesis and lymphopoiesis.

Peng Hui H Hu Biao B Xie Ling-Qi LQ Su Tian T Li Chang-Jun CJ Liu Ya Y Yang Mi M Xiao Ye Y Feng Xu X Zhou Rui R Guo Qi Q Zhou Hai-Yan HY Huang Yan Y Jiang Tie-Jian TJ Luo Xiang-Hang XH

Cell metabolism 20220614 8

Exercise can prevent osteoporosis and improve immune function, but the mechanism remains unclear. Here, we show that exercise promotes reticulocalbin-2 secretion from the bone marrow macrophages to initiate bone marrow fat lipolysis. Given the crucial role of lipolysis in exercise-stimulated osteogenesis and lymphopoiesis, these findings suggest that reticulocalbin-2 is a pivotal regulator of a local adipose-osteogenic/immune axis. Mechanistically, reticulocalbin-2 binds to a functional receptor ...[more]

PMID: 35705079

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