Dynamic Chromatin Localization of Sirt6 Shapes Stress- and Aging- Related Transcriptional Networks
Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Kun Qu
PROVIDER: E-GEOD-28641 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Dynamic chromatin localization of Sirt6 shapes stress- and aging-related transcriptional networks.
Kawahara Tiara L A TL Rapicavoli Nicole A NA Wu Angela R AR Qu Kun K Quake Stephen R SR Chang Howard Y HY
PLoS genetics 20110630 6
The sirtuin Sirt6 is a NAD-dependent histone deacetylase that is implicated in gene regulation and lifespan control. Sirt6 can interact with the stress-responsive transcription factor NF-κB and regulate some NF-κB target genes, but the full scope of Sirt6 target genes as well as dynamics of Sirt6 occupancy on chromatin are not known. Here we map Sirt6 occupancy on mouse promoters genome-wide and show that Sirt6 occupancy is highly dynamic in response to TNF-α. More than half of Sirt6 target gene ...[more]
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