Identification of Sox9-Regulated Pathways During Pancreas Development
Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Hung Ping Shih
PROVIDER: E-GEOD-28671 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
A Notch-dependent molecular circuitry initiates pancreatic endocrine and ductal cell differentiation.
Shih Hung Ping HP Kopp Janel L JL Sandhu Manbir M Dubois Claire L CL Seymour Philip A PA Grapin-Botton Anne A Sander Maike M
Development (Cambridge, England) 20120606 14
In the pancreas, Notch signaling is thought to prevent cell differentiation, thereby maintaining progenitors in an undifferentiated state. Here, we show that Notch renders progenitors competent to differentiate into ductal and endocrine cells by inducing activators of cell differentiation. Notch signaling promotes the expression of Sox9, which cell-autonomously activates the pro-endocrine gene Ngn3. However, at high Notch activity endocrine differentiation is blocked, as Notch also induces expre ...[more]
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