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To examine the influence of the early stress of maternal separation on the hippocampal transcriptome in young adulthood

ABSTRACT: In this study, we examined the consequences of the early stress (ES) of maternal separation on hippocampal gene expression in young adulthood. Young adult (2 months old) ES animals exhibit hippocampal transcriptome changes with a significant regulation of genes associated with intracellular signaling, MAP kinase signaling, plasma membrane function, neurotransmitter and neuropeptide receptors and cytoskeletal components. Agilent one-color experiment, Agilent-024724 Genotypic-designed Custom Rattus Norvegicus 8x15k; Organism: Rattus norvegicus; Labeling kit: Agilent Quick-Amp labeling Kit (p/n5190-0442); Biological replicates: 4 per treatment group.

ORGANISM(S): Rattus norvegicus

SUBMITTER: Deepika Suri 

PROVIDER: E-GEOD-29412 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Early stress evokes temporally distinct consequences on the hippocampal transcriptome, anxiety and cognitive behaviour.

Suri Deepika D   Bhattacharya Amrita A   Vaidya Vidita A VA  

The international journal of neuropsychopharmacology 20130912 2

The early stress of maternal separation (ES) exerts long-lasting effects on cognition and anxiety. Recent evidence indicates enhanced hippocampus-dependent spatial learning in young adult ES animals, which shifts towards a decline in long-term memory in middle-aged life. Further, we find that ES animals exhibit enhanced anxiety in young adulthood that does not persist into middle-aged life. Here, we demonstrate unique, predominantly non-overlapping, hippocampal transcriptomes in young adult and  ...[more]

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