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To examine the influence of the early stress of maternal separation on the hippocampal transcriptome in middle-aged life

ABSTRACT: In this study, we examined the consequences of the early stress (ES) of maternal separation on hippocampal gene expression in middle-aged animals. Middle-aged (15 months old) ES animals exhibit hippocampal transcriptome changes with a significant regulation of genes associated with ion binding, transcriptional regulation, cellular projection, cellular stress responsive pathways, neuronal development and chromatin remodeling. Agilent one-color experiment, Agilent-024724 Genotypic-designed Custom Rattus Norvegicus 8x15k; Organism: Rattus norvegicus; Labeling kit: Agilent Quick-Amp labeling Kit (p/n5190-0442); Biological replicates: 5 per early stress group, 3 per control group

ORGANISM(S): Rattus norvegicus

SUBMITTER: Deepika Suri 

PROVIDER: E-GEOD-29414 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Early stress evokes temporally distinct consequences on the hippocampal transcriptome, anxiety and cognitive behaviour.

Suri Deepika D   Bhattacharya Amrita A   Vaidya Vidita A VA  

The international journal of neuropsychopharmacology 20130912 2

The early stress of maternal separation (ES) exerts long-lasting effects on cognition and anxiety. Recent evidence indicates enhanced hippocampus-dependent spatial learning in young adult ES animals, which shifts towards a decline in long-term memory in middle-aged life. Further, we find that ES animals exhibit enhanced anxiety in young adulthood that does not persist into middle-aged life. Here, we demonstrate unique, predominantly non-overlapping, hippocampal transcriptomes in young adult and  ...[more]

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