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Transcription profiling of murine R1 embryonic stem cells differentiating into embryoid bodies over a time-course to study changes in transcription during stem cell differentiation

ABSTRACT: An 11-point time course study comparing R1 embryonic stem cells versus embryoid bodies. Time course 0 hours, 6 hours, 12 hours, 18 hours, 24 hours, 36 hours, 48 hours, 4 days, 7 days, 9 days, and 14 days. Experiment Overall Design: this experiment include 11 samples and 66 replicates

ORGANISM(S): Mus musculus

SUBMITTER: OGIC Info Ontario Genomics Innovation Centre (OGIC)

PROVIDER: E-GEOD-2972 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Gene function in early mouse embryonic stem cell differentiation.

Hailesellasse Sene Kagnew K Porter Christopher J CJ Palidwor Gareth G Perez-Iratxeta Carolina C Muro Enrique M EM Campbell Pearl A PA Rudnicki Michael A MA Andrade-Navarro Miguel A MA

BMC genomics 20070329

<h4>Background</h4>Little is known about the genes that drive embryonic stem cell differentiation. However, such knowledge is necessary if we are to exploit the therapeutic potential of stem cells. To uncover the genetic determinants of mouse embryonic stem cell (mESC) differentiation, we have generated and analyzed 11-point time-series of DNA microarray data for three biologically equivalent but genetically distinct mESC lines (R1, J1, and V6.5) undergoing undirected differentiation into embryo ...[more]

PMID: 17394647

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