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Ixr1 and the Saccharomyces cerevisiae hypoxic response

ABSTRACT: Analysis of the transcriptome of the wild-type strain BY4741 and its isogenic derivative ixr1 null, grown in aerobic, hypoxic conditions and after a hypoxic shift Two biological replicates in two technical replicates for each growth condition

ORGANISM(S): Saccharomyces cerevisiae

SUBMITTER: M Esperanza Cerdan

PROVIDER: E-GEOD-30046 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Ixr1p and the control of the Saccharomyces cerevisiae hypoxic response.

Vizoso-Vázquez Angel A Lamas-Maceiras Mónica M Becerra Manuel M González-Siso M Isabel MI Rodríguez-Belmonte Esther E Cerdán M Esperanza ME

Applied microbiology and biotechnology 20111222 1

In Saccharomyces cerevisiae, adaptation to hypoxia/anaerobiosis requires the transcriptional induction or derepression of multiple genes organized in regulons controlled by specific transcriptional regulators. Ixr1p is a transcriptional regulatory factor that causes aerobic repression of several hypoxic genes (COX5B, TIR1, and HEM13) and also the activation of HEM13 during hypoxic growth. Analysis of the transcriptome of the wild-type strain BY4741 and its isogenic derivative Δixr1, grown in aer ...[more]

PMID: 22189861

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