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Expression data in the mouse brain following the glucocorticoid receptor overexpression in the forebrain (GRov) during different periods in development

ABSTRACT: The glucocorticoid receptor overexpression in early life is sufficient to alter gene expression patterns for the rest of the animal's life. Hippocampal dentate gyrus (DG) are more responsive than the nucleus accumbens (NAcc) following the glucocorticoid receptor overexpression in the forebrain. Laser capture microdissection was performed. Microdissected areas from the dentate gyrus or nucleus accumbens were collected from serial sections for each animal.

ORGANISM(S): Mus musculus

SUBMITTER: Qiang Wei

PROVIDER: E-GEOD-30187 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Early-life forebrain glucocorticoid receptor overexpression increases anxiety behavior and cocaine sensitization.

Wei Qiang Q Fentress Hugh M HM Hoversten Mary T MT Zhang Limei L Hebda-Bauer Elaine K EK Watson Stanley J SJ Seasholtz Audrey F AF Akil Huda H

Biological psychiatry 20110827 3

<h4>Background</h4>Genetic factors and early-life adversity are critical in the etiology of mood disorders and substance abuse. Because of their role in the transduction of stress responses, glucocorticoid hormones and their receptors could serve as both genetic factors and mediators of environmental influences. We have shown that constitutive overexpression of the glucocorticoid receptor (GR) in forebrain results in increased emotional reactivity and lability in mice. Here, we asked whether the ...[more]

PMID: 21872848

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