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Unknown,Transcriptomics,Genomics,Proteomics

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ESlncRNA (AK148461) over-expression on gene expression

ABSTRACT: We over-expressed ESlncRNA (AK148461) in fetal liver erythroid progenitor cells (Lin-cells), followed by microarray analysis to examine the global changes of gene expression level. We showed that ESlncRNA has an anti-apoptotic activity during mouse erythropoiesis. Compare the gene expression level in vector transduced fetal liver erythroid progenitor cells (Lin-cells) with that in ESlncRNA transduced fetal liver erythroid progenitor cells (Lin-cells).

ORGANISM(S): Mus musculus

SUBMITTER: Wenqian Hu

PROVIDER: E-GEOD-30279 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Long noncoding RNA-mediated anti-apoptotic activity in murine erythroid terminal differentiation.

Hu Wenqian W Yuan Bingbing B Flygare Johan J Lodish Harvey F HF

Genes & development 20111208 24

Long noncoding RNAs (lncRNAs) are differentially expressed under both normal and pathological conditions, implying that they may play important biological functions. Here we examined the expression of lncRNAs during erythropoiesis and identified an erythroid-specific lncRNA with anti-apoptotic activity. Inhibition of this lncRNA blocks erythroid differentiation and promotes apoptosis. Conversely, ectopic expression of this lncRNA can inhibit apoptosis in mouse erythroid cells. This lncRNA repres ...[more]

PMID: 22155924

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