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Distribution of Drosophila insulator proteins Mod(mdg4) and L(3)mbt in Kc cells

ABSTRACT: Here we map the localization of Mod(mdg4), including Mod(mdg4)2.2 specific and Mod(mdg4) common to all isoforms, to chromatin insulators, as well as the lethal-3 malignant brain tumor protein in Drosophila Kc cells. examination of genomic occupancy for Mod(mdg4)2.2, Mod(mdg4)BTB (all isoforms), and L(3)mbt, control samples used for Drosophila Kc were previously described (Wood, Van Bortle et al., 2011 GSE30740)

ORGANISM(S): Drosophila melanogaster

SUBMITTER: Kevin Van Bortle

PROVIDER: E-GEOD-36393 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Drosophila CTCF tandemly aligns with other insulator proteins at the borders of H3K27me3 domains.

Van Bortle Kevin K Ramos Edward E Takenaka Naomi N Yang Jingping J Wahi Jessica E JE Corces Victor G VG

Genome research 20120621 11

Several multiprotein DNA complexes capable of insulator activity have been identified in Drosophila melanogaster, yet only CTCF, a highly conserved zinc finger protein, and the transcription factor TFIIIC have been shown to function in mammals. CTCF is involved in diverse nuclear activities, and recent studies suggest that the proteins with which it associates and the DNA sequences that it targets may underlie these various roles. Here we show that the Drosophila homolog of CTCF (dCTCF) aligns i ...[more]

PMID: 22722341

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2012-07-05 | E-GEOD-36735 | biostudies-arrayexpress

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