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Distribution of Drosophila insulator proteins DREF in Drosophila Kc167 cells

ABSTRACT: Here we map the localization of DREF Drosophila replication related element binding factor in Drosophila Kc cells. Examination of genomic occupancy for DREF, control samples used for Drosophila Kc were previously described (Wood, Van Bortle et al., 2011 GSE30740 and GSE32584). The GSM number for the input for Total Chip_seq data is GSM762849.

ORGANISM(S): Drosophila melanogaster

SUBMITTER: Gurudatta Baraka Vishwanathan

PROVIDER: E-GEOD-39664 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Dynamic changes in the genomic localization of DNA replication-related element binding factor during the cell cycle.

Gurudatta B V BV Yang Jingping J Van Bortle Kevin K Donlin-Asp Paul G PG Corces Victor G VG

Cell cycle (Georgetown, Tex.) 20130425 10

DREF was first characterized for its role in the regulation of transcription of genes encoding proteins involved in DNA replication and found to interact with sequences similar to the DNA recognition motif of the BEAF-32 insulator protein. Insulators are DNA-protein complexes that mediate intra- and inter-chromosome interactions. Several DNA-binding insulator proteins have been described in Drosophila, including BEAF-32, dCTCF and Su(Hw). Here we find that DREF and BEAF-32 co-localize at the sam ...[more]

PMID: 23624840

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