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Cervical cancer

ABSTRACT: This SuperSeries is composed of the following subset Series: GSE30758: Epigenome analysis of normal cells from the uterine cervix in a nested prospective case control study within the ARTISTIC trial GSE30759: Epigenome analysis of normal and cancer tissue from the uterine cervix Refer to individual Series

ORGANISM(S): Homo sapiens

SUBMITTER: Andrew Teschendorff

PROVIDER: E-GEOD-30760 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

The dynamics and prognostic potential of DNA methylation changes at stem cell gene loci in women's cancer.

Zhuang Joanna J Jones Allison A Lee Shih-Han SH Ng Esther E Fiegl Heidi H Zikan Michal M Cibula David D Sargent Alexandra A Salvesen Helga B HB Jacobs Ian J IJ Kitchener Henry C HC Teschendorff Andrew E AE Widschwendter Martin M

PLoS genetics 20120209 2

Aberrant DNA methylation is an important cancer hallmark, yet the dynamics of DNA methylation changes in human carcinogenesis remain largely unexplored. Moreover, the role of DNA methylation for prediction of clinical outcome is still uncertain and confined to specific cancers. Here we perform the most comprehensive study of DNA methylation changes throughout human carcinogenesis, analysing 27,578 CpGs in each of 1,475 samples, ranging from normal cells in advance of non-invasive neoplastic tran ...[more]

PMID: 22346766

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Epigenome analysis of smear cells from the uterine cervix consisting of 24 normals and 24 cervical intraepithelial neoplasias (all HPV+)

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