Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Daniel Hollern
PROVIDER: E-GEOD-30805 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Hollern D P DP Yuwanita I I Andrechek E R ER
Oncogene 20120423 10
Expression of c-Myc is highly prevalent in human breast cancer and stability of the oncoprotein is regulated through Ras-regulated phosphorylation at serine 62 and threonine 58. Previous studies have illustrated the importance of accumulation of KRas mutations in Myc-mediated tumor formation. To examine Myc dependence upon Ras mutations we have generated MMTV regulated Myc and Myc T58A transgenic mice. Expression of the more stable T58A Myc allele resulted in a reduction in KRas-activating mutat ...[more]