Dataset Information
Expression data from PKM1 or PKM2 expressing mouse embryonic fibroblasts.
Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Sophia Lunt
PROVIDER: E-GEOD-60499 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Pyruvate kinase isoform expression alters nucleotide synthesis to impact cell proliferation.
Molecular cell 20141204 1
Metabolic regulation influences cell proliferation. The influence of pyruvate kinase isoforms on tumor cells has been extensively studied, but whether PKM2 is required for normal cell proliferation is unknown. We examine how PKM2 deletion affects proliferation and metabolism in nontransformed, nonimmortalized PKM2-expressing primary cells. We find that deletion of PKM2 in primary cells results in PKM1 expression and proliferation arrest. PKM1 expression, rather than PKM2 loss, is responsible for ...[more]
