Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Markus Muschen
PROVIDER: E-GEOD-30883 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Nature medicine 20130714 8
The B cell-specific transcription factor BACH2 is required for affinity maturation of B cells. Here we show that Bach2-mediated activation of p53 is required for stringent elimination of pre-B cells that failed to productively rearrange immunoglobulin VH-DJH gene segments. After productive VH-DJH gene rearrangement, pre-B cell receptor signaling ends BACH2-mediated negative selection through B cell lymphoma 6 (BCL6)-mediated repression of p53. In patients with pre-B acute lymphoblastic leukemia, ...[more]