Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Noboru Sakabe
PROVIDER: E-GEOD-30943 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Sakabe Noboru J NJ Aneas Ivy I Shen Tao T Shokri Leila L Park Soo-Young SY Bulyk Martha L ML Evans Sylvia M SM Nobrega Marcelo A MA
Human molecular genetics 20120210 10
The ongoing requirement in adult heart for transcription factors with key roles in cardiac development is not well understood. We recently demonstrated that TBX20, a transcriptional regulator required for cardiac development, has key roles in the maintenance of functional and structural phenotypes in adult mouse heart. Conditional ablation of Tbx20 in adult cardiomyocytes leads to a rapid onset and progression of heart failure, with prominent conduction and contractility phenotypes that lead to ...[more]